Upregulation of cell adhesion through delta Np63 silencing in human 5637 bladder cancer cells
نویسندگان
چکیده
منابع مشابه
Upregulation of cell adhesion through delta Np63 silencing in human 5637 bladder cancer cells.
Some researchs have demonstrated that the loss of delta Np63 is associated with aggressive phenotypes and poor prognosis. However, other research indicates that delta Np63 is considered to have oncogenic properties. Delta Np63 overexpression is often observed in association with the oncogenic growth of squamous cell carcinomas and bladder cancer. In this study, we investigated the oncogenic rol...
متن کاملParthenolide induces apoptosis and cell cycle arrest of human 5637 bladder cancer cells in vitro.
Parthenolide, the principal component of sesquiterpene lactones present in medical plants such as feverfew (Tanacetum parthenium), has been reported to have anti-tumor activity. In this study, we evaluated the therapeutic potential of parthenolide against bladder cancer and its mechanism of action. Treatment of bladder cancer cells with parthenolide resulted in a significant decrease in cell vi...
متن کاملThe effect of cisplatin in 5637 bladder cancer cell line
Cisplatin is an inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. It’s been an important component of standard treatment regimens for several human malignancies including bladder cancer [1]. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cros...
متن کاملidentification of pi3k isoforms in human prostate cancer cell lines (pc3, du145) and human bladder carcinoma cell line (5637)
there exists an association between pi3k pathway licentious activity and the considerable feature of high metastatic potential of the genitourinary cancer cells. although du 145 and 5637 have functional phosphatase and tensin homolog (pten) tumor suppressor gene, which antagonizes pi3k function, pc-3 is null for pten gene. in pursuit to explain why pten bearing cell lines display high metastati...
متن کاملInvestigating Anticancer Effects of Silver Nanoparticles on Bladder Cancer 5637 Cells in Comparison to Human Embryonic Kidney Normal Cells (HEK-293)
Background & aim: Nanotechnology is a modern research field with broad applications in cancer management. Among the various metal nanoparticles, silver nanoparticles (AgNPs) have been used in cancer therapy due to their promising anti-tumor properties. Despite the great advantages of AgNPs, their effects on normal cells have become a challenge. Besides, their anti-cancer effects have not previo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2012
ISSN: 1008-682X,1745-7262
DOI: 10.1038/aja.2012.42